Despite the purported uses of boldo leaves, women during pregnancy, breastfeeding mothers or people with serious liver ailments need to avoid boldo leaves. Also, as the leaves stimulate bile production, people with blockages of the bile duct, or those who have undergone gallbladder removal procedure, should not use boldo leaves. Moreover, there is documented evidence of asaridole having a toxic effect on the liver. So, to be on the safer side, it is advised to avoid consumption of boldo leaves on a regular basis.